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Mode of action of the 2-nitroimidazole derivative benznidazole

A Polak, R Richle

Annals of Tropical Medicine and Parasitology

|February 1, 1978

Abstract:

Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.

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