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Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...

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Related Experiment Video

Updated: Mar 25, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Standard and Ultrahigh Resolution Photon-Counting Coronary CTA-Derived FFR Against Invasive FFR Assessment.

Leonardo Portolan¹, Rafail A Kotronias¹, Stefano Andreaggi¹

¹Acute Multidisciplinary Imaging and Interventional Centre (AMIIC), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

JACC. Cardiovascular Imaging

|March 24, 2026

Summary

This summary is machine-generated.

Photon-counting coronary CT angiography (PCCTA) with ultrahigh resolution (UHR) imaging provides more accurate fractional flow reserve (FFR) measurements than standard resolution (SR) imaging. UHR-PCCTA demonstrates superior diagnostic accuracy and hemodynamic classification compared to SR-PCCTA.

Keywords:

FFR coronary CTA photon-counting standard resolution ultrahigh resolution

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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Area of Science:

Cardiovascular Imaging
Medical Physics
Interventional Cardiology

Background:

Coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFR) is crucial for guiding invasive coronary angiography (ICA).
Image quality significantly impacts the accuracy of CTA-derived FFR.
Photon-counting coronary computed tomography angiography (PCCTA) offers standard resolution (SR) and ultrahigh resolution (UHR) imaging capabilities.

Purpose of the Study:

To conduct the first intraindividual comparison of FFR derived from SR-PCCTA, UHR-PCCTA, and invasive FFR.
To evaluate the diagnostic performance of SR- and UHR-PCCTA-derived FFR against invasive FFR.
To assess the concordance in hemodynamic significance classification between the two PCCTA modalities and invasive FFR.

Main Methods:

32 patients underwent research PCCTA with both SR and UHR acquisitions prior to ICA.
Invasive FFR was measured for intermediate coronary stenoses.
SR- and UHR-PCCTA-derived FFR were computed using a machine-learning prototype and compared to invasive FFR.
Subanalyses were performed in severely calcific and diffusely diseased vessels.

Main Results:

Both SR-PCCTA-derived FFR (ρ: 0.490) and UHR-PCCTA-derived FFR (ρ: 0.728) correlated with invasive FFR.
UHR-PCCTA-derived FFR maintained correlation in calcific (ρ: 0.577) and diffusely diseased vessels (ρ: 0.772), unlike SR-PCCTA.
UHR-PCCTA demonstrated superior diagnostic accuracy (AUC: 0.93 vs 0.80) and hemodynamic classification (Cohen's κ: 0.70 vs 0.50) compared to SR-PCCTA.

Conclusions:

Both SR- and UHR-PCCTA-derived FFR correlate with invasive FFR.
UHR-PCCTA-derived FFR shows improved diagnostic accuracy and hemodynamic significance classification over SR-PCCTA.
UHR-PCCTA represents a promising advancement for non-invasive assessment of coronary artery stenosis severity.