Silver-Catalyzed Radical Addition/Cyclization Cascade Reaction to Access Sulfonylated 4-Amino-2-quinolone Derivatives

Area of Science:

• Organic Chemistry
• Medicinal Chemistry

Background:

• Quinolone derivatives are important scaffolds in medicinal chemistry.
• Efficient synthesis of functionalized quinolones is crucial for drug discovery.

Purpose of the Study:

• To develop a novel synthetic route for sulfonylated 4-amino-2-quinolone derivatives.
• To explore a silver-catalyzed cascade reaction for quinolone synthesis.

Main Methods:

• Synthesis of sulfonylated 4-amino-2-quinolone derivatives.
• Utilizing ortho-cyanoarylacrylamides and sodium sulfinates.
• Employing a silver-catalyzed radical addition/cyclization cascade reaction.

Main Results:

• Successful synthesis of various sulfonylated 4-amino-2-quinolone derivatives.
• Good to excellent yields achieved for the desired products.
• Demonstrated tolerance of diverse substrates in the reaction.

Conclusions:

• The developed methodology provides an efficient pathway to sulfonylated 4-amino-2-quinolones.
• The reaction is scalable, offering potential for larger-scale synthesis.
• This work expands the synthetic toolbox for accessing valuable quinolone structures.