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    Area of Science:

    • Biomedical Engineering
    • Nanotechnology
    • Cancer Research

    Background:

    • Small molecules are effective cancer drug ligands but face challenges from protein corona formation on nanoconstructs.
    • Protein corona formation obstructs ligand-receptor interactions due to size differences.

    Purpose of the Study:

    • To investigate the impact of nanoparticle shape on folic acid ligand binding to folate receptors on cancer cells.
    • To determine if nanoparticle geometry can mitigate protein corona effects.

    Main Methods:

    • Utilized gold nanoconstructs with spiky and spherical cores functionalized with folic acid.
    • Employed dot blot assays for quantitative binding analysis.
    • Applied single-nanoconstruct tracking to observe binding dynamics.

    Main Results:

    • Spiky gold nanoconstructs with folic acid ligands demonstrated enhanced binding to folate receptors compared to spherical counterparts.
    • Single-particle tracking revealed increased confined motion of spiky constructs, indicating receptor binding.

    Conclusions:

    • Nanoparticle shape, specifically anisotropic nanofeatures, can enhance the targeting of nanoconstructs with small-molecule ligands.
    • Spiky nanoparticle designs show potential to overcome protein corona-mediated targeting obstruction in cancer therapy.