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Updated: Mar 27, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
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A case series highlighting inter-individual variability in circadian & medication-driven beta dynamics from chronic

Roni Naivelt1, Maya Zutta2, Zoya Katzir3

  • 1Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel; Functional Neurosurgery and Neuromodulation Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 24, 2026
PubMed
Summary

No abstract available in PubMed .

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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