Related Experiment Video
Updated: Mar 27, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
A Decade of cGAS Discovery: Point of Convergence in Oral Diseases
Lu Sun1, Pengfei Gao2, Peng Xiao3
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Introduction And Aims:
To provide the research progress on the cGAS-STING signalling pathway and its related roles in various oral diseases.
Methods:
We reviewed the recent research on cGAS-STING in PubMed. This article summarises recent research achievements in the discovery and confirmation of the cGAS-STING signalling pathway, as well as its biological and immunological roles in various diseases.
Results:
The cGAS-STING pathway and its associated cytokines play a crucial role in host immunity. It plays various roles in antiviral infections and autoimmune diseases, while also playing an important role in tumour surveillance and cellular aging processes. Research has shown that the cGAS-STING pathway affects various oral diseases such as periodontitis, pulp infections, oral mucosal diseases, maxillofacial tumours and many others.
Conclusion:
The cGAS-STING pathway plays a crucial role in various diseases, and its excessive activation often leads to immune dysregualtion. The role of cGAS-STING in oral diseases needs to be further elucidated CLINICAL RELEVANCE: The cGAS-STING pathway represents a promising target for the development of new therapeutic strategies for a range of oral diseases.
Related Concept Videos
Oral Cavity
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
The Oral Microbiota
What is Monogastric Digestion?
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
Development of the Oral Microbiota

