Related Experiment Video
Updated: Mar 27, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Host genetic ancestry and immunity to pathogens
Priscila M S Castanha1, Michelle M Martí2, Ernesto T A Marques3
1Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
Abstract:
Recent studies have reported increased susceptibility to or reduced severity of viral and bacterial infections between distinct ancestral populations. In this review, we will outline the current state of knowledge regarding the interplay between genetic ancestry and the immune response to pathogens. We will concentrate on the ancestry-associated drivers of these immunological variations through the lens of different viral and bacterial infections in humans. Understanding how different ancestral backgrounds influence the immune response to pathogens can reveal previously unrecognized mechanisms of disease susceptibility and resistance. This knowledge can inform the development of targeted and effective strategies for disease prevention, diagnosis, and treatment, as well as personalized medicine approaches.
More Related Videos
10:08Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
Published on: August 12, 2019
08:03Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Principles of Pharmacogenetics: Types of Genetic Variants
What is Population Genetics?
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...