Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.6K
Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.3K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.3K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

89
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
89
What is Population Genetics?01:25

What is Population Genetics?

65.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.8K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subset.

bioRxiv : the preprint server for biology·2026
Same author

SARS-CoV-2 Seroprevalence of Surinamese Children and Determinants of Seropositivity in the CCREOH/MeKiTamara Cohort.

Children (Basel, Switzerland)·2026
Same author

Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine.

Nature medicine·2026
Same author

Mitochondrial DNA Variation, Antiretroviral Therapy, and Incidence of Diabetes Among Men With and Without HIV.

Open forum infectious diseases·2026
Same author

Symptomatic chikungunya and chronic post-infection arthralgia in a highly endemic setting in Northeastern Brazil, 2018-2019: Clinical characteristics, prevalence and associated factors.

PloS one·2026
Same author

Chikungunya adolescent vaccination and the distinct risk-benefit landscapes.

The Lancet. Infectious diseases·2025

Related Experiment Video

Updated: Mar 27, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K

Host genetic ancestry and immunity to pathogens.

Priscila M S Castanha1, Michelle M Martí2, Ernesto T A Marques3

  • 1Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Pernambuco, Brazil.

Trends in Microbiology
|March 24, 2026
PubMed
Summary

Genetic ancestry influences immune responses to infections, affecting disease susceptibility and severity across diverse populations. Understanding these links can improve disease prevention and personalized medicine.

Keywords:
genetic ancestryimmune responseinfectious diseases

More Related Videos

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.7K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K

Related Experiment Videos

Last Updated: Mar 27, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.7K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Emerging research indicates variations in susceptibility and severity of viral and bacterial infections across different ancestral populations.
  • These differences suggest a significant role for host genetics in modulating immune responses to pathogens.

Purpose of the Study:

  • To review the current understanding of how genetic ancestry impacts the human immune response to pathogens.
  • To identify ancestry-associated factors driving variations in immunological responses to infections.

Main Methods:

  • Literature review focusing on studies examining genetic ancestry and immune responses.
  • Analysis of data related to viral and bacterial infections in diverse human populations.

Main Results:

  • Genetic background is a key determinant of immune system function and its response to infectious agents.
  • Specific ancestral populations exhibit differential susceptibility and resistance to various pathogens.

Conclusions:

  • Investigating the interplay between genetic ancestry and immunity offers insights into disease mechanisms.
  • This knowledge is crucial for developing targeted interventions, effective diagnostics, and personalized medicine strategies for infectious diseases.