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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

Updated: Mar 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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The Year in Coagulation and Transfusion: Selected Highlights.

Gabor Erdoes1, Andreas Koster2, Linda Shore-Lesserson3

  • 1Clinic for Anesthesiology, Hospital Center Biel, Biel/Bienne, Switzerland; University of Bern, Bern, Switzerland.

Journal of Cardiothoracic and Vascular Anesthesia
|March 24, 2026
PubMed
Summary

Recent advances in cardiothoracic and vascular care emphasize patient blood management, including restrictive transfusion strategies and optimized anemia treatment. Four-factor prothrombin complex concentrate is favored over fresh frozen plasma for specific bleeding scenarios.

Keywords:
bleedingfactor concentratesmechanical circulatory systempatient blood managementpediatricsthrombosis

More Related Videos

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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Related Experiment Videos

Last Updated: Mar 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Microfluidics in Assessing Platelet Function
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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Area of Science:

  • Cardiothoracic and Vascular Surgery
  • Hematology
  • Transfusion Medicine

Background:

  • Patient blood management is crucial in cardiothoracic and vascular surgery.
  • Evidence supports restrictive transfusion thresholds, anemia management, and bleeding protocols.

Purpose of the Study:

  • To review recent advances in coagulation and transfusion practices in cardiothoracic and vascular care.
  • To highlight evolving strategies in patient blood management and hemostatic control.

Main Methods:

  • Review of recent studies and clinical data.
  • Analysis of evidence supporting new transfusion thresholds and anemia management.
  • Evaluation of novel hemostatic agents and monitoring techniques.

Main Results:

  • Four-factor prothrombin complex concentrate is preferred over fresh frozen plasma for specific coagulopathies.
  • Viscoelastic testing aids in personalized transfusion strategies and heparin monitoring.
  • Hemadsorption shows potential for direct oral anticoagulant removal in urgent settings.

Conclusions:

  • There is a trend towards individualized, viscoelastic testing-guided hemostatic management.
  • Advances improve safety and efficacy in managing bleeding and thrombosis risks.
  • New approaches optimize outcomes in complex cardiothoracic and vascular procedures.