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Published on: June 12, 2021
Experts' recommendations for the management of adult patients with cardiogenic shock
Nadia Aissaoui1, Clement Delmas2, Hamid Merdji3
1Intensive Cardiac Care Unit, Cardiology department, Hôpital européen Georges-Pompidou, Assistance publique des Hôpitaux de Paris, Université Paris Cité, Paris, France.
Insights
New European guidelines offer updated management strategies for cardiogenic shock (CS) in adults. These recommendations emphasize multidisciplinary teams, early etiological treatment, and appropriate hemodynamic support for improved patient outcomes.
Area of Science:
- Cardiology
- Intensive Care Medicine
- Critical Care
Background:
- European guidelines for cardiogenic shock (CS) management are over a decade old.
- There is a need for updated, evidence-based recommendations for adult CS.
- Multidisciplinary expert groups are essential for developing comprehensive guidelines.
Purpose of the Study:
- To develop and present updated recommendations for the management of cardiogenic shock in adult patients.
- To provide guidance on CS teams, medical and etiological management, organ support, and circulatory support.
- To address the lack of recent specific international European guidelines.
Main Methods:
- Utilized the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.
- Developed by a joint expert group from French medical societies (SRLF, SFC, SFAR, SFCTCV).
- Identified 23 PICO questions leading to 41 recommendations across six key areas.
Main Results:
- Generated 41 recommendations for adult cardiogenic shock management.
- Recommendations include 7 with high evidence, 11 with moderate, and 17 with low evidence (expert opinion).
- Strong expert agreement achieved on all recommendations, highlighting the need for structured shock teams and early etiological treatment.
Conclusions:
- Optimal cardiogenic shock management requires a structured, multidisciplinary approach and standardized protocols.
- Early etiological treatment, such as revascularization or valve intervention, is crucial for improving outcomes.
- Hemodynamic support should prioritize norepinephrine, with mechanical circulatory support reserved for selected cases.
Abstract:
The last specific international European recommendations regarding the management of cardiogenic shock (CS) regardless of the etiology were issued over 10years ago. We present herein recommendations for the management of CS in adults, developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system by an expert group of from the French Intensive Care Society [Société de réanimation de langue française (SRLF)] and the French Society of Cardiology [Société française de cardiologie (SFC)], with the participation of the French Society of Anesthesia and Intensive Care [Société française d'anesthésie et de réanimation (SFAR)], and the French Society of Thoracic and Cardiovascular Surgery [Société française de chirurgie thoracique et cardio-vasculaire (SFCTCV)]. The recommendations covered six fields of application: CS teams and expert centers, symptomatic medical management, etiological management, organ support, temporary circulatory support and de-escalation and early post-CS management. Twenty-three "Patient Intervention Comparator Outcome" (PICO) questions were identified, leading to 41 recommendations regarding management of CS in adult patients. Seven recommendations were scored with high level of evidence (Grade 1), 11 with moderate level of evidence (Grade 2) and 17 with low level of evidence (Expert opinion). In 6 cases, the experts were not able to give an answer. All of the recommendations obtained strong agreement from the expert committee. The experts highlight the fact that optimal management of CS requires organization including a structured, multidisciplinary shock team and regional referral network, applying standardized protocols for diagnosis and staging. Early etiological treatment-such as culprit-lesion revascularization or urgent valve intervention-is central to improve outcomes. Hemodynamic support should prioritize norepinephrine as first-line vasopressor and privilege selective inotrope use. Temporary mechanical circulatory support (Impella, VA-ECMO) should be reserved for carefully selected patients following discussion by the expert team.
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