Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurotransmitters01:31

Neurotransmitters

3.5K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
3.5K
Brain Imaging01:14

Brain Imaging

902
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
902
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.9K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

5.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural Correlates of Diagnostic-Relevant Emotional Processing in Schizophrenia and Major Depressive Disorder: Insights from a Replication of fMRI and Self-Report Scales.

Journal of integrative neuroscience·2026
Same author

Beyond gray matter: unveiling the critical role of white matter in Alzheimer's disease.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.

Human brain mapping·2026
Same author

Domain-General Decoupling and Context-Specific Buffering: Transdiagnostic Eye-Tracking Biomarkers of ASD and ADHD During Naturalistic Viewing.

bioRxiv : the preprint server for biology·2026
Same author

Unique Amygdala Signatures and Shared Prefrontal Deficits in Autism: Mapping Social Heterogeneity via Naturalistic functional Magnetic Resonance Imaging.

bioRxiv : the preprint server for biology·2026
Same author

Glymphatic Dysfunction, Brain Damage, and Clinical Disability in Spinocerebellar Ataxia Type 3.

Movement disorders : official journal of the Movement Disorder Society·2026

Related Experiment Video

Updated: Mar 27, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

1.0K

Dynamic brain connectivity patterns induced by oxytocin: An fMRI Co-Activation pattern analysis study.

Benjamin Klugah-Brown1, Yuan Li2, Hao Wu2

  • 1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, No.2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu, China. bklugah@gmail.com.

Molecular Psychiatry
|March 25, 2026
PubMed
Summary

Oxytocin (OT) enhances brain network flexibility and switching in young adults, while promoting sustained engagement with emotion networks in older adults. This suggests OT

More Related Videos

Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study
04:44

Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study

Published on: July 21, 2021

5.2K
Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions
10:45

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Published on: July 6, 2011

12.3K

Related Experiment Videos

Last Updated: Mar 27, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

1.0K
Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study
04:44

Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study

Published on: July 21, 2021

5.2K
Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions
10:45

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Published on: July 6, 2011

12.3K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Aging Research

Background:

  • Oxytocin (OT) is a neuropeptide involved in emotional regulation and social cognition.
  • The impact of oxytocin on dynamic brain connectivity, particularly across different age groups, is not well understood.
  • Understanding how oxytocin influences brain network dynamics is crucial for its therapeutic potential.

Purpose of the Study:

  • To investigate how intranasal oxytocin (OT) modulates whole-brain functional dynamics using co-activation pattern (CAP) analysis.
  • To examine age-specific effects of oxytocin on brain connectivity and its relationship with cognitive performance.
  • To explore the role of OT in supporting cognitive functions, especially in older adults.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data were collected from healthy young and older adults.
  • Co-activation pattern (CAP) analysis was employed to assess dynamic changes in brain connectivity.
  • Participants received either intranasal oxytocin or a placebo, with analyses conducted at group and subgroup levels.

Main Results:

  • Oxytocin significantly altered temporal properties of brain states, increasing network flexibility and switching, particularly in young adults.
  • OT modulated brain states involving the amygdala, medial prefrontal cortex, and salience network, regions associated with emotion regulation.
  • Older adults showed sustained engagement with emotion-related states, and this engagement correlated with cognitive performance (Digit Symbol Substitution Test), suggesting a compensatory role of OT.

Conclusions:

  • Oxytocin shapes transient brain dynamics in an age- and function-specific manner.
  • The findings highlight differential sensitivity to oxytocin between young and older adults, with potential compensatory benefits in the elderly.
  • Co-activation pattern analysis is a valuable method for capturing neuromodulatory effects on brain dynamics.