Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermoscopic Features of Cutaneous Leishmaniasis Under Ultraviolet-Induced Fluorescence Dermoscopy.

International journal of dermatology·2026
Same author

The Use of YouDermoscopy Application for Dermoscopy learning: A pilot study.

Dermatology practical & conceptual·2026
Same author

Amicrobial Pustulosis of the Folds Associated With Pediatric Systemic Lupus Erythematosus.

International journal of dermatology·2026
Same author

Matrix Phenolization vs. Gutter Splint Method for the Treatment of Onychocryptosis: A Randomized Open-Label Study.

International journal of dermatology·2026
Same author

Topical Corticosteroid Phobia in Tunisia: A Pilot Study in Atopic Dermatitis Patients and Healthcare Professionals.

International journal of dermatology·2026
Same author

Rare internal malignancies in xeroderma pigmentosum: A report of two cases from Tunisia and analysis of driver mutations.

Cancer pathogenesis and therapy·2026

Related Experiment Video

Updated: Jun 9, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.6K

Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review.

Noureddine Litaiem1,2, Karama Sboui1,2, Faten Zeglaoui1,2

  • 1Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

International Journal of Dermatology
|March 25, 2026
PubMed
Summary
This summary is machine-generated.

Pellagra, a vitamin B3 deficiency, is primarily caused by diet, but medication and malabsorption are rising factors. Early treatment with niacin supplementation resolves symptoms quickly, especially in at-risk populations.

Keywords:
global healthniacinpellagrasystematic review

More Related Videos

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

3.3K
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow
08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.3K

Related Experiment Videos

Last Updated: Jun 9, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.6K
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

3.3K
Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow
08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.3K

Area of Science:

  • Nutritional Sciences
  • Dermatology
  • Internal Medicine

Background:

  • Pellagra's clinical presentation, etiology, and treatment require updated understanding in the 21st century.
  • Existing literature lacks comprehensive data on contemporary pellagra cases.

Purpose of the Study:

  • To update the understanding of pellagra's clinical and etiological aspects.
  • To reappraise current treatment and prevention strategies for pellagra.

Main Methods:

  • Systematic review of PubMed and Scopus databases up to January 2023.
  • Inclusion of case reports, case series, and case-control studies (2000-2023).
  • Screening of reference lists for additional relevant studies.

Main Results:

  • 133 studies comprising 1212 pellagra cases were analyzed.
  • Cutaneous (98.63%), gastrointestinal (59.4%), and neurological (54.2%) manifestations were most common.
  • Dietary deficiency (85%) was the primary cause, linked to food insecurity (93%); isoniazid (14.3%) and alcohol misuse (9.6%) were notable contributors.

Conclusions:

  • Dietary deficiency remains the main cause of pellagra, particularly in vulnerable populations.
  • Medication-induced and malabsorption-related pellagra cases are increasingly reported.
  • Targeted niacin supplementation and addressing underlying causes are crucial for effective pellagra management.