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One- and two-year structural changes of mavacamten therapy in hypertrophic obstructive cardiomyopathy: a case report

Katharina Seuthe1, Roman Pfister1, Carl-Hubertus Schönherr2

  • 1Department III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany.

European Heart Journal. Case Reports
|March 25, 2026
PubMed

Insights

Mavacamten therapy for hypertrophic obstructive cardiomyopathy (HOCM) shows sustained cardiac reverse remodeling up to two years. This myosin inhibitor improves cardiac structure and function, offering long-term benefits beyond initial symptom relief.

Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Imaging

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) involves left ventricular outflow tract (LVOT) obstruction and reduced quality of life.
  • Mavacamten, a novel myosin inhibitor, is a promising therapeutic option for HOCM.
  • Existing data on mavacamten's effects, particularly from cardiovascular magnetic resonance (CMR), are limited to short-term follow-up.
Abstract

Keywords:
Cardiac magnetic resonanceCase reportHypertrophic obstructive CardiomyopathyMyosin-Inhibitor

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