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From Preconception to Postnatal: Parental Risk Factors for Fetal-Infant Growth Faltering in LMICs-a Scoping Review
Mira Trisyani Koeryaman1, Laili Rahayuwati2, Sheizi Prista Sari2
1Department of Maternity Nursing, Faculty of Nursing, Universitas Padjadjaran, Bandung, 45363, Indonesia.
Insights
Parental and environmental factors significantly impact fetal and infant growth. Addressing individual, community, and policy determinants is crucial for preventing growth faltering and improving child health outcomes.
Area of Science:
- Global Health
- Maternal and Child Health
- Developmental Pediatrics
Background:
- Fetal and infant growth faltering is a significant global health challenge, particularly in Low- and Middle-Income Countries (LMICs).
- Understanding the complex interplay of parental and environmental risk factors is essential for effective intervention strategies.
Purpose of the Study:
- To systematically review and map the association between parental (maternal and paternal) risk factors and fetal-infant growth faltering.
- To identify key determinants across preconception, pregnancy, and postnatal periods influencing growth disorders.
Main Methods:
- A scoping review was conducted following PRISMA-ScR guidelines.
- Searched major databases (PubMed, Scopus, Web of Science) for studies published between 2020-2025.
- Included studies on fetal-infant growth faltering in LMICs, analyzing parental risk factors using thematic synthesis.
Main Results:
- Seventeen studies were included, revealing multifaceted determinants of growth disorders.
- Key factors identified include individual (maternal age, nutrition, health), environmental (sanitation, housing), community (poverty, inequality), and policy (antenatal care access).
- These factors are shaped by broader social determinants of health.
Conclusions:
- Fetal and infant growth are influenced by a complex interplay of behavioral, socioeconomic, and environmental factors.
- These determinants significantly increase the risk of growth disorders.
- Interventions must consider a holistic approach addressing individual, community, and policy levels.
Purpose:
This review aimed to map the association between parental (both maternal and paternal) risk factors, from preconception through the postnatal period, and fetal-infant growth faltering.
Patients And Methods:
This scoping review followed the PRISMA-ScR frameworks to systematically gather and analyze evidence from major databases (PubMed, Scopus and Web of Science). The inclusion criteria encompassed studies involving pregnant women, fetuses, or infants aged 0-24 months, including those diagnosed with fetal or infant growth faltering that examined maternal and/or paternal risk factors, conducted in Low- and Middle-Income Countries (LMICs), using study designs such as observational, cross-sectional, cohort, case-control, or randomized controlled trials, and published in English between 2020 and 2025. Data were analysed through thematic synthesis.
Results:
From 4235 initial records, we identified 17 eligible studies for this review. The findings showed that the determinants of fetal and infant growth disorders are multifaceted, falling into four key areas. These included individual factors including maternal age, education, nutritional status, health condition, reproductive history, mental health and psychological, marital and socioeconomic,occupation, substance use, and infant factors; environmental concerns including household sanitation and hygiene, water, fuel source, house conditions. Community factors including poverty, deprivation, ethnicity, social inequality, and geographical characteristics. Policy factors, including coverage and quality Antenatal care (ANC), and access to maternal and child health services. These factors represent secondary conditions shaped by broader social and structural determinants of health, rather than direct causal factors. The key determinants shown to influence fetal and infant growth are individual, environmental, community, and policy factors.
Conclusion:
Fetal and infant growth are influenced by a combination of behavioural, socioeconomic, and environmental factors. These factors contribute considerably to the increased risk of growth disorders in fetal and infant.
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