Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.7K
1.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

94
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
94

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10.

OncoTargets and therapy·2018
Same author

Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin).

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu·2018
Same author

Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment.

Cell transplantation·2018
Same author

Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China.

Renal failure·2018
Same author

Asymptotic analysis of V-BLAST MIMO for coherent optical wireless communications in Gamma-Gamma turbulence.

Optics express·2018
Same author

Model-Based and Model-Free Techniques for Amyotrophic Lateral Sclerosis Diagnostic Prediction and Patient Clustering.

Neuroinformatics·2018

Related Experiment Video

Updated: Mar 27, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

26.3K

Strategies, Challenges and Application Prospects for Exosome Engineering Modifications in Tumor Targeted

Xiaoyan Ge1,2, Shuo Shan1, Haozhong Lu2

  • 1Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, The Affiliated Hospital of Qingdao University; Qingdao University, Qingdao, People's Republic of China.

International Journal of Nanomedicine
|March 25, 2026
PubMed
Summary

Exosomes, natural vesicles, show promise for targeted tumor drug delivery, overcoming limitations of conventional nanodrugs. Engineering exosomes enhances their tumor-targeting ability for improved cancer therapy.

Keywords:
engineering modificationsexosomenanotechnologytumor targeted therapeutics

More Related Videos

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

8.0K
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

943

Related Experiment Videos

Last Updated: Mar 27, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

26.3K
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

8.0K
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

943

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Conventional nanodrugs have limited tumor accumulation (~0.7%), restricting cancer therapy efficacy.
  • Exosomes, natural extracellular vesicles, offer advantages like low immunogenicity and biocompatibility for drug delivery.

Purpose of the Study:

  • To review exosome isolation, characterization, and engineering strategies for enhanced tumor targeting.
  • To summarize exosome-based targeted cancer therapies and discuss challenges for clinical translation.

Main Methods:

  • Systematic review of exosome isolation and characterization techniques.
  • Analysis of engineering strategies including physical manipulation, chemical conjugation, and biological engineering.

Main Results:

  • Exosomes can be engineered for improved tumor-targeting specificity and controlled payload release.
  • Exosome engineering enables "smart" therapeutic platforms with multimodal functionalities.

Conclusions:

  • Exosomes represent a promising platform for advanced tumor-targeted drug delivery.
  • Addressing challenges in scalability, standardization, and regulatory approval is crucial for clinical translation of exosome-based therapies.