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Updated: Mar 27, 2026

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Neurophysiological screening of individual variability for robust decoding in c-VEP-based BCI.

Sébastien Velut1,2, Jordy Thielen3, Sylvain Chevallier2

  • 1Fédération ENAC ISAE-SUPAERO ONERA, Université de Toulouse, Toulouse, France.

Imaging Neuroscience (Cambridge, Mass.)
|March 25, 2026
PubMed
Summary
This summary is machine-generated.

Brain-computer interfaces (BCIs) using code-modulated visual evoked potentials (c-VEPs) show promise but struggle with user variability. This study identifies neurophysiological predictors and a decoding pipeline to improve cross-user accuracy for c-VEP control.

Keywords:
brain–computer interface (BCI)code-modulated visual evoked potential (c-VEP)electroencephalography (EEG)predictorstransfer learningvariability

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Human-Computer Interaction

Background:

  • Code-modulated visual evoked-potential (c-VEP) brain-computer interfaces (BCIs) offer high data rates and minimal calibration.
  • A significant challenge is the performance drop when BCI models are transferred between different users.
  • Understanding inter-participant variability is crucial for robust BCI applications.

Purpose of the Study:

  • To identify neurophysiological predictors of performance variability in c-VEP BCIs.
  • To develop a decoding pipeline that maintains accuracy across users in a burst-c-VEP paradigm.
  • To enable rapid and robust deployment of c-VEP BCIs.

Main Methods:

  • Analyzed neurophysiological data from 24 participants performing a burst-c-VEP task.
  • Identified predictors including inter-epoch correlation, VEP amplitude, and specific brainwave bandpowers (α, θ, δ).
  • Compared three preprocessing schemes and three decoders (CNN, Riemannian xDAWN-LDA, GREEN) for intra- and cross-participant accuracy.

Main Results:

  • Five neurophysiological predictors were found to correlate with performance differences between high and low performers.
  • Subject-specific alignment combined with the GREEN decoder achieved 93% trial-level accuracy.
  • This approach eliminated the typical 15-20% cross-participant transfer loss and kept calibration under 1 minute.

Conclusions:

  • Rapid user screening using identified neurophysiological predictors can quickly identify suitable candidates.
  • A lightweight, user-specific decoding pipeline (Subject-specific alignment + GREEN) ensures robust and accurate c-VEP control.
  • This optimized approach facilitates fast deployment and reliable performance of c-VEP BCIs across diverse users.