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Related Concept Videos

Chronic Obstructive Pulmonary Disease-I: Introduction01:20

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease01:24

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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The Role of Advanced Lung Cancer Inflammation Index in Predicting COPD Exacerbation Risks.

Wang Chun Kwok1, Sze Him Isaac Leung2, Terence Chi Chun Tam1

  • 1Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People's Republic of China.

International Journal of Chronic Obstructive Pulmonary Disease
|March 25, 2026
PubMed
Summary
This summary is machine-generated.

The Advanced Lung Cancer Inflammation Index (ALI) can predict risks for COPD exacerbations and mortality. Lower ALI levels are linked to increased risks, even in non-eosinophilic patients, aiding clinical prognostication.

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COPDCOPD exacerbationadvanced lung cancer inflammation indexbiomarkers

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Area of Science:

  • Pulmonary Medicine
  • Biomarker Research
  • Chronic Disease Management

Background:

  • The Advanced Lung Cancer Inflammation Index (ALI) role in chronic obstructive pulmonary disease (COPD) is not well-defined.
  • ALI has been used for non-malignant conditions, but its utility in COPD requires further investigation.

Purpose of the Study:

  • To investigate the relationship between baseline ALI levels and the risk of acute exacerbations of COPD (AECOPD) in Chinese patients.
  • To determine if ALI can serve as a predictive biomarker for AECOPD and mortality in COPD.

Main Methods:

  • A prospective study was conducted in Hong Kong with 272 Chinese COPD patients.
  • Patients were recruited from respiratory clinics and followed until March 2025 or death.
  • ALI levels were assessed across quartiles to correlate with AECOPD and survival outcomes.

Main Results:

  • Patients in the lowest ALI quartile (Q1) had a significantly higher risk of moderate to severe AECOPD (aHR 2.17) and severe AECOPD (aHR 2.05) compared to the highest quartile (Q4).
  • Lower ALI levels were also associated with increased mortality risk (aHR 2.73).
  • These associations persisted in the subgroup with low baseline blood eosinophil counts (<300 cells/μL).

Conclusions:

  • The Advanced Lung Cancer Inflammation Index (ALI) is a potential biomarker for predicting moderate to severe AECOPD, severe AECOPD, and mortality in COPD patients.
  • ALI's predictive value is evident even in non-eosinophilic COPD patients.
  • This simple, repeatable biomarker can aid clinicians in prognostication and risk assessment for COPD patients.