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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Evaluation of Atherosclerosis Risk in Patients with Psoriasis

Lutfullah Celik1, Anil Akray2, Yasargul Denli1

  • 1Cukurova University, Medical School, Department of Dermatology, Adana, Turkey.

Clinical, Cosmetic and Investigational Dermatology
|March 25, 2026
PubMed

Insights

Psoriasis patients show increased carotid intima-media thickness (CIMT), a marker of atherosclerosis. This risk is higher with longer disease duration and smoking, necessitating regular cardiovascular monitoring.

Area of Science:

  • Cardiology
  • Dermatology
  • Public Health

Background:

  • Psoriasis is a chronic systemic inflammatory disease extending beyond the skin.
  • Atherosclerosis in psoriasis patients increases risks of severe cardiovascular events like stroke and myocardial infarction.

Purpose of the Study:

  • To evaluate atherosclerosis risk in psoriasis patients.
  • To measure carotid intima-media thickness (CIMT) as a marker for atherosclerosis in this population.

Main Methods:

  • Included 70 plaque psoriasis patients and 50 healthy controls (ages 18-65).
  • Excluded patients using systemic treatment within 6 months.
  • Measured CIMT using B-mode ultrasonography, with manual measurements by a single cardiologist.

Main Results:

  • Psoriasis patients exhibited significantly higher CIMT (median 0.8 mm) compared to controls (median 0.6 mm).
  • Significant correlations found between CIMT and age, BMI, smoking, waist/hip circumference, HbA1c, total cholesterol, and triglycerides.
  • Multivariate analysis identified cigarette use and disease duration as significant predictors of CIMT, with PASI showing a trend.

Conclusions:

  • Psoriasis patients demonstrate elevated CIMT, indicating increased atherosclerosis risk.
  • The increase in CIMT is exacerbated by disease duration and smoking.
  • Regular atherosclerosis screening and follow-up are recommended for psoriasis patients, particularly smokers and those with long-standing disease.
Abstract

Keywords:
atherosclerosiscarotid intima media thicknesspsoriasis

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