Impact of Vascular Anastomosis Time on Kidney Transplant Outcomes - A Systematic Review

Anastomotic time (AT), also termed second warm ischaemic time (SWIT), is a potentially important intraoperative factor in kidney transplantation, yet its impact on outcomes has not been systematically synthesised. We conducted a systematic review to examine the association between AT and delayed graft function (DGF), graft survival, and patient survival. Cochrane, Embase, and Medline were searched to 21 July 2025. Nine retrospective cohort studies comprising 155,523 transplants were included. Across all donor types, longer AT was consistently associated with higher rates of DGF within individual studies. Several studies also reported poorer 1- and 5-year graft survival with prolonged AT, while findings for patient survival were equivocal. However, substantial heterogeneity across studies, including donor type, AT definitions, outcome reporting, and incomplete adjustment for key confounders, precluded formal meta-analysis. None of the included studies consistently adjusted for major determinants of graft outcomes. These findings suggest a potential link between prolonged AT and adverse graft outcomes, but high-quality prospective studies with standardised reporting and confounder adjustment are required before AT can be considered an independent determinant of transplant outcomes.

https://www.crd.york.ac.uk/prospero/, identifier PROSPERO CRD42024549222.