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Updated: Mar 27, 2026
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
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Targeted detection method for locus-specific m6A modifications in low-abundance transcripts based on chemical
1College of Chemistry and Molecular Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, Hubei, 430072, China. rqzhao@whu.edu.cn.
Chemical Communications (Cambridge, England)
|March 25, 2026
Abstract:
In this study, we developed a method for locus-specific m6A detection, which employs sodium nitrite and glyoxal-based chemical conversion with probe hybridization. This approach enables highly sensitive detection of target m6A sites even in low-abundance transcripts.
