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Published on: June 11, 2012
Cost-Effectiveness of Continuous Glucose Monitoring With Remote Patient Monitoring in Pediatric Patients With Newly
Paul Dupenloup1, Yupeng Chen1, Priya Prahalad2,3
1Department of Management Science and Engineering, Stanford University, Stanford, CA.
Insights
Continuous glucose monitoring (CGM) with remote patient monitoring (RPM) is cost-effective for type 1 diabetes management. This approach improves health outcomes and reduces long-term complication costs compared to traditional blood glucose monitoring.
Area of Science:
- Endocrinology
- Health Economics
- Medical Technology
Background:
- Continuous glucose monitoring (CGM) and remote patient monitoring (RPM) are increasingly utilized in diabetes care.
- Traditional self-monitoring of blood glucose (SMBG) has limitations in providing comprehensive glycemic data.
Purpose of the Study:
- To evaluate the cost-effectiveness of CGM with RPM compared to SMBG and CGM alone for type 1 diabetes management.
- To assess the impact on health outcomes, including diabetic ketoacidosis and chronic complications.
Main Methods:
- A Markov model simulated type 1 diabetes progression in 5-year-old patients over various time horizons (20-year, 50-year, lifetime).
- The study compared three interventions: SMBG, CGM, and CGM with RPM, analyzing quality-adjusted life years (QALYs) and healthcare costs.
- Efficacy estimates were based on pediatric CGM studies and the 4T Study, with sensitivity analyses performed.
Main Results:
- CGM with RPM increased QALYs and healthcare costs compared to SMBG and CGM alone.
- CGM with RPM demonstrated a lower incremental cost-effectiveness ratio ($27,400/QALY) compared to CGM alone ($103,700/QALY).
- Results remained robust across sensitivity analyses and time horizons, indicating cost-effectiveness.
Conclusions:
- CGM with RPM offers superior health outcomes for newly diagnosed type 1 diabetes patients.
- Despite initial higher costs, CGM with RPM is likely cost-effective, potentially leading to net healthcare savings by reducing complication costs.
Objective:
The use of continuous glucose monitoring (CGM) with remote patient monitoring (RPM) continues to grow. We evaluated the cost-effectiveness of CGM with RPM compared with self-monitoring of blood glucose (SMBG) and CGM alone.
Research Design And Methods:
We simulated type 1 diabetes progression with a Markov model in 5-year-old patients over a 20-year, 50-year, and lifetime horizon. We tracked diabetic ketoacidosis (DKA), severe hypoglycemia (SH), and seven chronic complications: retinopathy, neuropathy, nephropathy, cardiovascular disease, end-stage renal disease, lower-extremity amputation, and blindness. We compared three interventions: SMBG, CGM, and CGM with RPM. Efficacy estimates were derived from meta-analyses of pediatric CGM studies and the results of the Teamwork, Targets, Technology, and Tight Glycemia Study (4T Study 1). We evaluated quality-adjusted life years (QALYs) and health care costs (2022 U.S. dollars) discounted at 3% annually. We performed extensive sensitivity analyses.
Results:
Compared with SMBG, CGM increased QALYs by 0.09 and costs by $8,900 over 20 years; CGM with RPM increased QALYs by 0.37, and costs by $10,300. CGM with RPM yielded more QALYs at a lower incremental cost-effectiveness ratio compared with CGM ($27,400/QALY vs. $103,700/QALY, respectively). Results were robust across sensitivity analyses and time horizons. CGM with RPM remained cost-effective when achieving at least 30% of 4T's clinical efficacy.
Conclusions:
CGM with RPM delivers superior health outcomes compared with SMBG and CGM and is likely cost-effective for patients with newly diagnosed type 1 diabetes. Despite higher intervention costs, CGM with RPM can reduce complications costs and generate net health care savings.
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