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Antifebrile effects of dexibuprofen suppository on children with high fever

Zhiyang Wu1, Junfeng Fu2, Pengxiang Lin1

  • 1Department of Critical Care Medicine, Quanzhou Maternity and Children's Hospital, Quanzhou, Fujian, China.

Pakistan Journal of Pharmaceutical Sciences
|March 25, 2026
PubMed

Insights

Dexibuprofen suppositories offer rapid and effective fever reduction in children, demonstrating better safety compared to ibuprofen suspension in pediatric emergency care.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Emergency Medicine

Background:

  • Acute fever is a common pediatric condition requiring effective treatment.
  • Evaluating antipyretic options is crucial for pediatric emergency care.

Purpose of the Study:

  • To assess the efficacy and safety of dexibuprofen suppositories for pediatric fever.
  • Compare dexibuprofen suppositories with ibuprofen suspension in children.

Main Methods:

  • Retrospective analysis of 100 febrile children (March 2022-March 2023).
  • Compared 57 children on dexibuprofen suppositories vs. 43 on ibuprofen suspension.
  • Analyzed body temperature changes and adverse reactions over 6 hours.

Main Results:

  • Dexibuprofen group showed significantly lower temperatures at 0.5, 2, 4, and 6 hours (P < 0.0001).
  • Overall efficacy was similar between groups (P > 0.05).
  • Dexibuprofen group experienced fewer adverse reactions (P = 0.0272).

Conclusions:

  • Dexibuprofen suppositories provide rapid and effective fever reduction in pediatric patients.
  • Dexibuprofen demonstrates improved safety in pediatric emergency settings.
  • Disease course and admission temperature are independent risk factors for fever management.
Abstract

Keywords:
Acute feverAntipyretic effectDexibuprofen suppositoryPrognosisTherapeutic effect

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