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Thermosensation01:43

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Design and implementation of a microscale thermophoresis system based on complementary metal-oxide-semiconductor

Shibin Mao1, Weiwei Xue1, Shangquan Wu1

  • 1CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, China.

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|March 25, 2026
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This study shows Complementary Metal-Oxide-Semiconductor (CMOS) imaging significantly enhances Microscale Thermophoresis (MST) for detecting molecular interactions. The new CMOS-based MST platform offers improved efficiency and sensitivity for drug development and biological research.

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Area of Science:

  • Biochemistry
  • Biophysics
  • Analytical Chemistry

Background:

  • Microscale Thermophoresis (MST) is vital for detecting molecular interactions in drug discovery.
  • Current MST instruments use single-point sensors (photodiodes or photomultiplier tubes - PMTs).
  • Limitations exist in current sensor technology for sensitive molecular interaction detection.

Purpose of the Study:

  • To systematically evaluate Photomultiplier Tube (PMT) versus Complementary Metal-Oxide-Semiconductor (CMOS) imaging in MST.
  • To develop and validate an optimized CMOS-based MST platform for enhanced molecular interaction analysis.
  • To assess the performance and reliability of CMOS imaging for sensitive biochemical assays.

Main Methods:

  • Comparative performance analysis of PMT and CMOS imaging in MST.
  • Development of an automated CMOS-based MST platform with intelligent region selection.
  • Validation using protein-protein interactions, antigen-antibody binding, and small molecule interactions.

Main Results:

  • CMOS imaging demonstrated superior signal-to-noise ratio, dynamic range, and spatial resolution.
  • CMOS enabled simultaneous full-field data acquisition, improving measurement efficiency.
  • The CMOS-based MST platform achieved comparable detection sensitivity to existing technologies.

Conclusions:

  • CMOS imaging technology offers significant advantages for Microscale Thermophoresis applications.
  • The developed CMOS-based MST platform provides a reliable and efficient solution for biochemical research.
  • This advanced platform is particularly beneficial for drug development assays with strong fluorescence signals.