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Related Experiment Video

Updated: Jun 2, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
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A Perioperative Hydrogel Platform for Integrated Endoscopic Submucosal Dissection Management.

Zizhao Wang1, Yang Yang2, Hongxin Sun3

  • 1School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, P. R. China.

ACS Applied Materials & Interfaces
|March 25, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel hydrogel for endoscopic submucosal dissection (ESD). The multifunctional hydrogel enhances ESD procedures and provides sustained pain relief and wound healing post-surgery.

Keywords:
bupivacaineendoscopic submucosal dissectionself-healing hydrogelsubmucosal fluid cushionsustained-release

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Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Minimally Invasive Surgery

Background:

  • Endoscopic submucosal dissection (ESD) faces challenges with conventional submucosal cushions and postoperative care.
  • Existing methods lack sustained therapeutic support and efficient mucosal elevation.

Purpose of the Study:

  • To develop a multifunctional hydrogel for perioperative management of ESD.
  • To address limitations of current submucosal agents and improve ESD outcomes.

Main Methods:

  • A hydrogel was synthesized using carboxymethyl chitosan and oxidized dextran via Schiff base reactions.
  • Methylene blue was incorporated for visualization, and Bupivacaine-loaded mesoporous silica nanoparticles (BUP@MSNs) were integrated for sustained analgesia.
  • In situ gelation, injectability, self-healing, tissue adhesion, antioxidant, and antibacterial properties were evaluated.

Main Results:

  • The hydrogel formed a stable submucosal cushion, enhancing ESD efficiency and safety with immediate wound sealing.
  • It demonstrated excellent injectability, self-healing, tissue adhesion, and potent antioxidant/antibacterial activities.
  • Sustained postoperative analgesia exceeding 48 hours was achieved, with favorable in vitro and in vivo biocompatibility.

Conclusions:

  • The developed hydrogel offers integrated mucosal elevation, sustained analgesia, and wound protection for ESD.
  • It represents a clinically operable and cost-effective solution for gastrointestinal endoscopic therapies.
  • This multifunctional hydrogel significantly improves perioperative management and patient outcomes in ESD.