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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Community Based Intervention01:30

Community Based Intervention

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Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
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International Nursing Organizations II01:28

International Nursing Organizations II

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The World Health Organization (WHO) is a specialized agency of the United Nations based in Geneva. The WHO has many initiatives that center around health. Primarily, they lead global efforts to expand universal health coverage using science-based policies and programs. They are also responsible for shaping health research agendas and developing norms and standards.
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
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Health Literacy01:21

Health Literacy

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Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
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Training and Clinical Research Capacity Building in Low- and Middle-Income Countries: Addressing Unmet Needs.

Chadli Dziri1, Lilia Zakhama2

  • 1Professor Emeritus, Editor-In-Chief Emeritus of La Tunisie Medicale, University of Tunis El Manar, Tunis, Tunisia.

La Tunisie Medicale
|March 25, 2026
PubMed
Summary

Clinical research in the Middle East, Mediterranean, and Africa (MEMA) region faces significant barriers, including funding and infrastructure challenges. Addressing these issues is crucial for improving global health equity and research participation.

Area of Science:

  • Global Health
  • Clinical Research
  • Health Equity

Background:

  • The Middle East, Mediterranean, and Africa (MEMA) region represents 20% of the global population but contributes only 6% of registered clinical trials.
Keywords:
Clinical ResearchLow Income CountriesUnmet Needs

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  • This disparity highlights significant challenges in conducting clinical research within the region.