[Synergistic Effect of Noise and Toluene Upon Hematological Alterations, Pulmonary Oxidative Stress and Inflammation]

Study the synergistic effects of noise-toluene co-exposure on hematological parameters, oxidative stress and pulmonary architecture in rats.

24 male Wistar rats were divided into four groups: control, noise exposure, toluene exposure and co-exposure noise-toluene. Biological analyses were performed to determine hematological parameters and evaluate markers of oxidative stress. Histopathological sections were observed to assess pulmonary tissue damage and the degree of inflammatory response.

Hematological analysis revealed a significant decrease in red blood cells (RBCs), accompanied by an increase in white blood cells (WBCs) and platelets. Histological examination of lung tissues revealed inflammation with alveolar wall damage and peribronchial immune cell infiltration in the co-exposed group, which correlated with increased vascular permeability and pulmonary edema. Exposure to toluene and noise resulted in significant disruption of the pulmonary tissue structure accompanied by oxidative stress.

The results suggest that combined exposure to toluene and noise causes structural and functional changes in lung tissues and alterations in hematological parameters.