Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

662
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
662
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.3K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.3K
Drug Therapy01:28

Drug Therapy

392
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
392
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

764
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
764

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Factors for Adulthood Psychosis in Adolescent Psychiatry Services: A Longitudinal Total Birth Cohort Study.

Schizophrenia bulletin·2026
Same author

Adolescent polysubstance use and psychopathology: a population-based survey in schools.

Irish journal of psychological medicine·2026
Same author

Positive childhood experiences and associations with plasma inflammatory markers in early adulthood.

Brain, behavior, and immunity·2026
Same author

Childhood immunomodulatory biomarkers and risk of depression and psychosis-spectrum outcomes at age 24: longitudinal evidence from the ALSPAC birth cohort.

Brain, behavior, and immunity·2026
Same author

Systematic review: Efficacy of off-label antipsychotic use in children and adolescents with obsessive-compulsive, mood dysregulation, depression, anxiety, and sleep-related disorders.

European child & adolescent psychiatry·2026
Same author

Doxycycline and Schizophrenia: Response to Letters.

The American journal of psychiatry·2026

Related Experiment Video

Updated: Mar 27, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K

Methylphenidate Treatment and Risk of Psychotic Disorder.

Colm Healy1,2, Kirstie O'Hare1, Ulla Lång1,3

  • 1Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.

JAMA Psychiatry
|March 25, 2026
PubMed
Summary
This summary is machine-generated.

Methylphenidate treatment for attention-deficit/hyperactivity disorder (ADHD) showed no overall link to psychosis risk. However, early childhood treatment may reduce psychosis risk in children with ADHD.

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.9K

Related Experiment Videos

Last Updated: Mar 27, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.9K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Methylphenidate is a primary treatment for attention-deficit/hyperactivity disorder (ADHD).
  • Individuals with ADHD face an elevated risk of psychosis, but long-term methylphenidate effects on this risk remain unclear.

Purpose of the Study:

  • To investigate the association between methylphenidate treatment and the risk of developing nonaffective psychosis in children and adolescents diagnosed with ADHD.

Main Methods:

  • A nationwide cohort study utilized Finnish registry data from individuals born between 1987 and 1997.
  • Instrumental variable analysis was employed to assess the relationship between methylphenidate exposure and nonaffective psychosis diagnosis.
  • Prescribing propensities within hospital districts served as instrumental variables.

Main Results:

  • The study included 3,956 individuals with ADHD; 69% received methylphenidate. Overall, sustained methylphenidate treatment was not associated with an increased risk of nonaffective psychosis.
  • Secondary analyses revealed a potential reduction in psychosis risk for individuals diagnosed with ADHD in childhood (under 13 years).
  • Insufficient instrument strength limited secondary analyses for adolescent-onset ADHD.

Conclusions:

  • No overall association was found between methylphenidate treatment and the risk of nonaffective psychosis in individuals with ADHD.
  • Methylphenidate treatment initiated in childhood may offer a protective effect against later psychosis.
  • Further research is warranted to explore treatment effects in adolescent and adult ADHD diagnoses.