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Related Concept Videos

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Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
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Related Experiment Video

Updated: Mar 27, 2026

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Clostridioides difficile Infection Among Hospitalized Patients With Cancer.

Giovanni A Roldan1, Spencer Goble1, Timothy Davie1

  • 1Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis.

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|March 25, 2026
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This summary is machine-generated.

Clostridioides difficile infection (CDI) affects 1.4% of cancer hospitalizations, increasing mortality and critical care needs. Targeted prevention and early intervention are crucial for this high-risk patient group.

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Health Services Research

Background:

  • Patients with cancer have a higher risk of Clostridioides difficile infection (CDI) due to treatments like chemotherapy and frequent healthcare exposure.
  • Limited national data exists on CDI prevalence, outcomes, and healthcare resource utilization in cancer patients.

Purpose of the Study:

  • To determine the hospitalization-level prevalence of CDI among cancer patients in the US.
  • To characterize clinical outcomes and healthcare resource utilization associated with CDI in this population.

Main Methods:

  • A cross-sectional study using the National Inpatient Sample (NIS) from 2016-2022.
  • Identified cancer hospitalizations and those with CDI using ICD-10 codes.
  • Analyzed in-hospital mortality, need for kidney replacement therapy, mechanical ventilation, and vasopressor use.

Main Results:

  • CDI was present in 1.4% of over 32 million cancer hospitalizations.
  • CDI cases involved older patients with more comorbidities and higher rates of hematologic cancers.
  • Patients with CDI had significantly higher in-hospital mortality (7.3% vs. 4.5%) and increased critical care interventions.

Conclusions:

  • CDI is a significant concern in cancer hospitalizations, associated with worse outcomes.
  • Findings highlight the need for enhanced CDI prevention and early treatment strategies in oncology settings.
  • Geographic variations in mortality suggest regional differences in care or patient populations.