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Optimising Paediatric Medication Adherence Through Innovative Drug Formulations and Delivery Systems

Nokwanda Nhlanzeko Ngcobo1

  • 1Division of Pharmacology (Therapeutics), Discipline of Pharmaceutical Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, University of KwaZulu-Natal, Durban, South Africa. ngcobon11@ukzn.ac.za.

Clinical Pharmacokinetics
|March 25, 2026
PubMed

Insights

Improving medication adherence in children is crucial. Innovative drug formulations and delivery systems tailored to paediatric pharmacokinetics can significantly enhance treatment outcomes and reduce healthcare costs.

Area of Science:

  • Pharmacology
  • Paediatric Medicine
  • Drug Delivery Systems

Background:

  • Medication adherence is a major healthcare challenge, especially in children.
  • Non-adherence in paediatric populations negatively impacts therapeutic outcomes and increases costs.
  • Paediatric patients have unique pharmacokinetic characteristics influencing drug response.

Purpose of the Study:

  • To highlight the critical role of drug formulations and delivery systems in paediatric medication adherence.
  • To explore how formulation design impacts efficacy, safety, and acceptability in children.
  • To provide evidence-informed strategies for enhancing paediatric adherence.

Main Methods:

  • Review of pharmacological considerations in paediatric drug formulation.
  • Analysis of innovative formulation and delivery system strategies.
  • Integration of tailored care approaches with formulation design.

Main Results:

  • Formulation design is pivotal for paediatric medication efficacy and safety.
  • Innovative strategies can overcome challenges in paediatric drug administration.
  • Tailored approaches combined with optimized formulations improve adherence.

Conclusions:

  • Optimized drug formulations and delivery systems are key to improving paediatric medication adherence.
  • Addressing pharmacokinetic differences through formulation is essential for better clinical outcomes.
  • Integrated strategies offer practical pathways to enhance adherence and patient care in children.

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