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Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and
Yoshiaki Kinoshita1, Kosuke Ishikawa2, Sadanori Akita3,4
1Department of Pediatric Surgery, Niigata University, Niigata, Japan.
Abstract:
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of December 2020 was searched in PubMed, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution Service (Minds) technique. A total of 38 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, pathological diagnosis deciding the diagnosis, and causal genes of vascular anomalies. Thus, the Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022 have been prepared as the evidence-based guidelines for the management of vascular anomalies.
Insights
These clinical practice guidelines offer evidence-based recommendations for treating vascular anomalies like hemangiomas and malformations. They systematize treatment strategies to improve patient outcomes and ensure safety.
Area of Science:
- Vascular Surgery
- Dermatology
- Pediatrics
- Genetics
Background:
- Vascular anomalies, including hemangiomas and malformations, require standardized treatment approaches.
- Current treatment strategies vary, necessitating evidence-based guidelines for optimal patient care.
- Improving treatment efficacy, safety, and outcomes is crucial for managing these conditions.
Purpose of the Study:
- To develop comprehensive, evidence-based clinical practice guidelines for vascular anomalies.
- To organize effective and efficient treatment strategies for hemangiomas and vascular malformations.
- To systematize management and improve outcomes using evidence-based medicine.
Main Methods:
- Formulated clinical questions (CQs) based on critical clinical issues.
- Conducted systematic literature searches (1980-2020) in PubMed and JCRM.
- Applied the Medical Information Network Distribution Service (Minds) technique to assess evidence and recommendations.
Main Results:
- Compiled recommendations for 38 CQs covering various treatment modalities.
- Addressed treatment efficacy for resection, sclerotherapy, embolization, drug therapy, laser, and radiotherapy.
- Included considerations for lesion location, symptoms, diagnostic methods, and genetic factors.
Conclusions:
- The Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022 provide a framework for managing vascular anomalies.
- These guidelines emphasize evidence-based approaches to enhance treatment safety and effectiveness.
- The guidelines aim to standardize care and improve patient outcomes for vascular anomalies.
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