Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nuclear Transmutation

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinicogenomic and Histopathologic Analyses of Supermassive Intrahepatic Cholangiocarcinoma and the Role of Ablative Radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy.

Frontiers in oncology·2026

Same author

Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity-modulated proton therapy.

Precision radiation oncology·2025

Same author

A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy.

Cancers·2024

Same author

Stereotactic body proton therapy for early stage non-small cell lung cancer - Technical challenges and solutions: The MD Anderson experience.

Journal of radiosurgery and SBRT·2023

Same author

Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma.

Journal of applied clinical medical physics·2023

Same journal

Present and Emerging Strategies for Disease Assessment in Hodgkin Lymphoma.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Nodular Lymphocyte-predominant Hodgkin Lymphoma: Incidence, Pathogenesis, Management.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Management of Classic Hodgkin Lymphoma in Special Clinical Situations.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Older Patients With Hodgkin Lymphoma: A Contemporary Review.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Adolescent and Young Adult Patients With Classical Hodgkin Lymphoma: A Review as a Case Study in AYA Cancer Care.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Hodgkin Lymphoma: Management of Patients Who Fail Primary Therapy.

Cancer journal (Sudbury, Mass.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 27, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Advancements in Accelerator and Beam Delivery Technology.

Xiaorong R Zhu¹, Yoshifumi Hojo, Mei Chen

¹Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.

Cancer Journal (Sudbury, Mass.)

|March 25, 2026

Summary

This summary is machine-generated.

This review covers advancements in particle therapy accelerators and beam delivery, focusing on pencil beam scanning for intensity modulated proton therapy. It also discusses proton arc therapy, FLASH therapy, and motion management for improved cancer treatment.

Keywords:

Accelerators image guidance proton therapy particle therapy pencil beam scanning proton therapy

More Related Videos

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Published on: January 28, 2021

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Related Experiment Videos

Last Updated: Mar 27, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Published on: January 28, 2021

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Area of Science:

Medical Physics
Radiation Oncology
Accelerator Physics

Background:

Particle therapy offers precise radiation delivery for cancer treatment.
Continuous innovation in accelerator and beam delivery systems is crucial for enhancing treatment efficacy and patient outcomes.

Purpose of the Study:

To review the development of accelerator technologies for particle therapy.
To present advancements in beam delivery techniques, including pencil beam scanning (PBS).
To discuss emerging concepts like proton arc therapy, FLASH therapy, and motion management.

Main Methods:

Review of accelerator principles (isochronous cyclotrons, synchrocyclotrons, synchrotrons).
Focus on pencil beam scanning (PBS) for intensity modulated proton therapy (IMPT).
Inclusion of proton arc therapy, ultrahigh-dose rate FLASH therapy, and motion management strategies.

Main Results:

Detailed explanation of accelerator working principles and recent technological progress.
Comprehensive overview of PBS for IMPT, highlighting its capabilities.
Exploration of advanced techniques and their integration into particle therapy.

Conclusions:

Significant progress in accelerator and beam delivery technology enhances particle therapy precision.
Emerging techniques like proton arc and FLASH therapy show promise for future cancer treatment.
Integration of imaging guidance, adaptive therapy, and motion management is key for optimizing particle therapy delivery.