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Mapping the evidence on post-intensive care syndrome in paediatric populations: A scoping review protocol
1Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
Insights
This scoping review maps post-intensive care syndrome in children (PICS-p), examining diagnostic tools, interventions, and outcomes. It highlights current knowledge gaps to guide future research and clinical practice for pediatric survivors.
Area of Science:
- Pediatric Critical Care Medicine
- Clinical Outcomes Research
- Evidence Synthesis
Background:
- Post-intensive care syndrome (PICS) affects physical, cognitive, and psychological health after critical illness.
- PICS in children (PICS-p) is under-recognized, with fragmented evidence on long-term impacts.
- A comprehensive overview is needed to address PICS-p assessment, management, and monitoring.
Purpose of the Study:
- To map the primary literature on PICS-p in children aged 1 month to 18 years.
- To focus on diagnostic methods, interventions, and post-ICU outcomes for PICS-p.
- To identify research gaps and inform clinical pathways for pediatric intensive care survivors.
Main Methods:
- Scoping review following PRISMA-ScR and Joanna Briggs Institute guidelines.
- Systematic searches of multiple databases (PubMed, Scopus, Cochrane, etc.) and trial registries.
- Independent dual-reviewer screening and data charting for synthesis.
Main Results:
- The review synthesizes data on PICS-p diagnostic tools, preventive and therapeutic interventions.
- It analyzes reported longitudinal outcomes for pediatric intensive care unit survivors.
- Descriptive synthesis of findings will be presented in tables and narrative summaries.
Conclusions:
- This review provides a structured overview of the current PICS-p literature.
- It identifies critical gaps in understanding and managing PICS-p.
- Findings will inform future research priorities and clinical care guidelines for pediatric critical care survivors.
Objective:
This scoping review aims to comprehensively map the primary literature on post-intensive care syndrome in paediatric populations (PICS-p), across all recognised PICS-p domains, with a focus on diagnostic methodologies, preventive and therapeutic interventions, and reported post-ICU outcomes among children aged 1 month-18 years.
Introduction:
Post-intensive care syndrome (PICS) encompasses new or worsening physical, cognitive, psychological, or social impairments emerging after critical illness. While extensively studied in adults, its paediatric counterpart, PICS-p, remains under-recognised and inconsistently characterised. Children surviving paediatric intensive care may face long-term functional limitations, developmental challenges, and psychosocial difficulties, with substantial implications for families and caregivers. Existing evidence is fragmented across diverse clinical contexts, age groups, and outcome measures, and no comprehensive synthesis has mapped how PICS-p is assessed, managed, or monitored. A structured overview is needed to clarify current practice, highlight gaps, and inform future research and clinical pathways.
Inclusion Criteria:
We will include primary clinical studies involving paediatric patients aged 1 month-18 years who have survived admission to a paediatric or specialised intensive care unit. Eligible studies may evaluate diagnostic or screening tools, preventive or therapeutic interventions, or longitudinal outcomes related to PICS-p. Studies including mixed-age populations will be incorporated only when paediatric data are reported separately or can be disaggregated. Grey literature reporting primary clinical data will be included. Exclusions apply to neonatal-only cohorts, adult-only studies, abstract-only publications, non-clinical reports, and studies focusing solely on in-ICU outcomes without post-discharge assessment. Only English-language studies published from 1 January 2000 onward will be considered.
Methods:
Following PRISMA-ScR and Joanna Briggs Institute guidance, this scoping review will conduct systematic searches across PubMed, Scopus, the Cochrane Library, ProQuest, CINAHL, medRxiv, and major clinical trial registries. Searches will be limited to English-language studies published from 1 January 2000 to the date of search. All records will be deduplicated in Zotero, and title/abstract and full-text screening will be performed independently by two reviewers using Rayyan, with discrepancies resolved by consensus or adjudication by a third independent reviewer. Data will be charted using a structured Microsoft Excel form and synthesised descriptively in tables and narrative summaries.
