Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner.

Nature genetics·2026
Same author

Epileptogenic lesions in the Australian epilepsy project: A harmonized 3-T magnetic resonance imaging protocol and its diagnostic yield.

Epilepsia·2026
Same author

Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis.

Human brain mapping·2026
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations.

Nature human behaviour·2026

Related Experiment Video

Updated: May 18, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K

Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.

Victoria Ives-Deliperi1, Jonathan Ipser1, James T Butler2

  • 1Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Epilepsia Open
|March 25, 2026
PubMed
Summary

Temporal lobe epilepsy (TLE) shows reduced within-network connectivity and increased between-network connectivity across major brain networks. These reproducible findings in TLE patients suggest widespread network reorganization impacting cognition and seizures.

Keywords:
functional MRIresting‐state functional connectivitytemporal lobe epilepsy

More Related Videos

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.9K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.1K

Related Experiment Videos

Last Updated: May 18, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.6K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.9K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.1K

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Brain Network Analysis

Background:

  • Temporal lobe epilepsy (TLE) affects multiple brain networks, with known alterations in resting-state networks (RSNs) crucial for higher cognitive functions.
  • Understanding these network disruptions is key to addressing cognitive comorbidities and seizure propagation in TLE.

Purpose of the Study:

  • To identify reproducible patterns of altered functional connectivity in TLE using a large, international cohort via the ENIGMA-Epilepsy project.
  • To investigate alterations in whole-brain connectivity within and between major RSNs in TLE patients compared to healthy controls.

Main Methods:

  • Analysis of resting-state functional MRI data from 442 individuals with TLE and 387 healthy adults across nine international centers.
  • Examination of group differences in whole-brain connectivity across seven major RSNs, including the default mode network (DMN).
  • Assessment of associations between connectivity patterns and clinical variables like age of seizure onset and disease duration.

Main Results:

  • TLE patients exhibited significantly lower within-network connectivity (average 13.6% decrease) and higher between-network connectivity (average 129% increase) in non-limbic RSNs.
  • These connectivity patterns were highly reproducible across all seven participating sites and most prominent in the DMN and visual networks.
  • Connectivity alterations were largely independent of age of seizure onset or disease duration and showed minimal differences between left and right TLE.

Conclusions:

  • The study provides robust evidence for widespread, consistent disruption of brain network organization in TLE across diverse geographical sites.
  • Findings indicate reduced intra-network connectivity and increased inter-network connectivity as a hallmark of TLE.
  • This network reorganization may underlie the cognitive impairments and seizure propagation patterns observed in individuals with TLE.