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Updated: Mar 27, 2026

Combining Solid-state and Solution-based Techniques: Synthesis and Reactivity of ChalcogenidoplumbatesII or IV
Published on: December 29, 2016
Electrochemical Phosphorochalcogenations for the Synthesis of Phosphorochalcogenothioates
Indrajit Karmakar1, Xiang-Wei Huang1, Yu-Hao Chen1
1Department of Chemistry, National Chung Hsing University, Taichung City 40227, Taiwan (R.O.C.).
Abstract:
We report a robust and environmentally conscious electrosynthetic protocol for the efficient construction of structurally diverse and biologically relevant phosphorochalcogenated compounds. This transformation proceeds through the electrochemical cross-coupling of phosphonothioates with the corresponding thiols or diaryl diselenides using inexpensive NaI or nBu4NI as both a green electrolyte and redox mediator. The reactions are carried out in CH3CN at room temperature under a constant current of 10 mA with Pt/Pt electrodes. This newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free operation, short reaction times, moderate to high yields, broad substrate scope, large-scale applicability, operational simplicity, and overall environmental sustainability.
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