Disrupted cerebello-cerebral functional integration of triple core networks in major depressive disorder: A...

Emerging evidence has highlighted the cerebellum's role in emotion and cognition through cerebello-cerebral interactions. However, the manner in which the cerebellum integrates with the cerebral triple core networks, the default mode network (DMN), central executive network (CEN), and salience network (SN), in Major Depressive Disorder (MDD) remains unclear.

Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 119 patients with MDD and 106 healthy control (HC) subjects. Voxel-wise functional connectivity (FC) between the cerebral cortex and cerebellum was subsequently constructed. To evaluate cerebello-cerebral functional integration based on voxel-wise FC, functional gradient analysis and independent component analysis (ICA) were performed.

The cerebral triple core network components were found to map onto cerebellar motor and cognitive functional modules. In patients with MDD, reduced mapping of the cerebral DMN and SN components to the cerebellum was observed. Additionally, patients exhibited compression of the cerebello-cerebral functional gradient within both motor and cognitive modules. The triple core networks showed increased contributions to cerebellar cognitive modules, whereas the DMN demonstrated decreased contributions to cerebellar motor modules in MDD. These cerebello-cerebral interaction patterns were significantly correlated with clinical assessment measures, including scores on the Trail Making Test (TMT) and the Emotion Regulation Questionnaire (ERQ).

These findings indicate disrupted functional integration between the cerebral triple core networks and the cerebellum in MDD. The results further support the cerebellum's involvement in disease pathogenesis and suggest potential neurobiological markers for diagnosis and intervention.