[Mechanism of actions and reflections of Masquelet induced membrane technique in diabetic wound]

Diabetic wounds are hindered in the healing process due to chronic inflammation , vasculari-zation disorder, and abnormal expression of growth factors caused by the high glucose microenvironment. Masquelet induced membrane technique (hereinafter referred to as the induced membrane technique) creates a bioactive membrane composed of various cellular components and rich in growth factors and microvessels by inserting bone cement into the wound. The membrane mainly promotes wound healing by remodeling the inflammatory microenvironment, promoting functional angiogenesis, and producing endogenous growth factors. This article briefly explains the mechanism by which the induced membrane technique improves wound healing and summarizes its clinical application in diabetic wounds. It is expected to provide new ideas and effective means for the clinical treatment of difficult-to-heal diabetic wounds. Future research needs to focus on the key molecular pathways for the application of the induced membrane technique in therapy and the development of new membrane induction materials, so as to provide new strategies for the treatment of diabetic wounds.