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Updated: Mar 27, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Regulatory role of IL-17-mediated inflammatory pathways in lung cancer initiation and progression
Xinjia Xu1, Xinan Lu1, Wei Wu1
1Respiratory and Critical Care Medicine, Cixi People's Hospital, Wenzhou Medical University, Ningbo, China.
Abstract:
Lung cancer continues to present a substantial global health and economic challenge, with consistently high rates of incidence and mortality. While there have been significant strides in precision diagnostics and treatment methods that have contributed to a reduction in mortality over previous years, progress has plateaued recently, largely due to complications such as side effects and resistance to therapies. Emerging research indicates that interleukin-17 (IL-17), a cytokine with pro-inflammatory properties, plays a critical role in various stages of lung cancer, including initiation, growth, invasion, metastasis, angiogenesis, lymphangiogenesis, and treatment resistance. This positions IL-17 as both a crucial regulator and a valuable prognostic marker for the disease's progression. This review aims to provide an overview of the most recent developments in IL-17 research as it relates to lung cancer, offering a theoretical framework for its potential as a therapeutic target in both the prevention and treatment of lung cancer.
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