Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzymatic Encoding of Topology in an Intrinsically Disordered Single-Chain Protein.

Angewandte Chemie (International ed. in English)·2026
Same author

Exploring the depth profile of low-pressure plasma-treated PDMS by VUV spectroscopic ellipsometry.

The Journal of chemical physics·2026
Same author

Enhancing Interfacial Charge Transport in Gold Nanoparticle@Polyaniline Hybrids via N-Heterocyclic Carbene Linkers.

Angewandte Chemie (International ed. in English)·2026
Same author

Catalytic oxygen generation and drug delivery via manganese dioxide nanoparticles to enhance radiotherapy in glioblastoma.

International journal of pharmaceutics·2026
Same author

Efficient and reversible chirality induction between protein and achiral plasmonic assemblies.

Nature materials·2026
Same author

Bottom-Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Deciphering the Catalytic Mechanism of Oxidoreductase-Like Nanozymes Along the Reaction Pathway: Activity, Specificity and Sustainability.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

High-Efficiency Asymmetric Spin Transport Enabled by Nanocolumn Molecular Semiconductors.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Entropy-Enabled Hierarchical Defect Architecture for Dual Enhancement of Thermoelectric and Mechanical Performance in SnTe Alloys.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Suppressing Charge Carrier Recombination in Bulk Heterojunction Organic Photocatalyst via Improving Molecular Crystallinity and Reducing Electron-Phonon Coupling for Efficient Hydrogen Evolution Reaction.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Machine Learning-Guided High-Efficiency and Thermally Stable Capacitive Energy Storage in Dielectric Capacitors With a Simple Chemical Composition.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Dynamic Self-Healing Polymer Architectures for High-Performance Flexible Sensing.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

3.9K

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.

Teuku Fawzul Akbar1, Carlos Alejandro Jimenez-Rodriguez1, Railia Biktimirova1

  • 1Division Polymer Biomaterials Science, Leibniz Institute of Polymer Research Dresden, Dresden, Germany.

Advanced Materials (Deerfield Beach, Fla.)
|March 26, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel semi-synthetic hydrogel (PEDOT:sGAGh) that bridges biology and electronics. This biohybrid material enables electrical control over cell differentiation cues, advancing brain-machine interfaces beyond purely electrical interactions.

Keywords:
bioelectronicsconductive hydrogelselectronic extracellular matrix

More Related Videos

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K
Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
10:45

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

13.7K

Related Experiment Videos

Last Updated: Mar 27, 2026

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

3.9K
Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K
Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
10:45

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

13.7K

Area of Science:

  • Biomaterials Science
  • Neurotechnology
  • Bioelectronics

Background:

  • Next-generation biohybrid technologies require materials that stably and multimodally exchange information between living systems and computers.
  • Native extracellular matrix (ECM) provides a model for biomaterials but lacks tunable electronic functionality.
  • Existing conductive hydrogels often lack tissue-like properties or precise control over biomolecular interactions.

Purpose of the Study:

  • To engineer a semi-synthetic hydrogel (PEDOT:sGAGh) that emulates ECM features with electrically tunable functionality.
  • To demonstrate electrical control over protein interactions and cell differentiation using the novel hydrogel.
  • To position PEDOT:sGAGh as a versatile platform for biohybrid circuits and advanced brain-machine interfaces.

Main Methods:

  • Engineered interactions between sulfated glycosaminoglycans (sGAGs) and poly(3,4-ethylenedioxythiophene) (PEDOT) within a hydrogel network.
  • Demonstrated control over the material's nanoarchitecture, electrochemical behavior, and biomolecular interactions.
  • Investigated low-voltage stimulation for modulating protein release/retention and subsequent cell differentiation.

Main Results:

  • Developed PEDOT:sGAGh hydrogel with emulated ECM features and electrically tunable properties.
  • Achieved electrical control over the release and retention of bioactive proteins, including growth factors.
  • Demonstrated electrical modulation of cell differentiation using the hydrogel, with ultra-low PEDOT content (≈1 wt.%).
  • Integrated PEDOT:sGAGh as a bioactive coating on electrodes and in 3D organic electrochemical transistors (OECTs).

Conclusions:

  • PEDOT:sGAGh offers a versatile platform for biohybrid circuits, bridging molecular signaling and solid-state electronics.
  • The material enables electrical control over macromolecular cues for cell differentiation, a novel capability.
  • This advancement paves the way for brain-machine interfaces with multimodal interaction capabilities beyond purely electrical modes.