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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

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Treatment-Related Cardiotoxicity in Non-Small Cell Lung Cancer: A Population-Based Analysis for Risk Stratification.

You Mo^1,2, Duncan Wei¹, Xinyi Liang²

¹Department of Cardiovascular Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

QJM : Monthly Journal of the Association of Physicians

|March 26, 2026

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This summary is machine-generated.

Immune checkpoint blockade plus radiation therapy (ICB-RT) shows superior cardiovascular safety for non-small cell lung cancer (NSCLC) patients. Targeted therapies and chemotherapy increase risks for heart failure and coronary artery disease, respectively.

Area of Science:

Oncology
Cardiology
Pharmacovigilance

Background:

Cardiovascular toxicity of non-small cell lung cancer (NSCLC) treatments is not fully understood.
Different anticancer therapies may pose varying risks to cardiac health.

Purpose of the Study:

To evaluate the association between NSCLC therapies and major cardiovascular adverse events.
To compare the cardiovascular safety profiles of targeted therapy, chemotherapy, radiotherapy, immune checkpoint blockade, and combination regimens.

Main Methods:

Observational cohort study including 5,242 NSCLC patients.
Pharmacovigilance analysis of cardiovascular toxicity risks associated with various anticancer therapies.
Comparison of risks for arrhythmias, heart failure, pericardial diseases, cardiomyopathy, and coronary artery diseases across treatment groups.

Keywords:

Cancer Cardiovascular disease Heart failure Therapeutic drug monitoring

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Main Results:

Immune checkpoint blockade plus radiotherapy (ICB-RT) demonstrated the best cardiovascular safety profile.
Targeted therapies (TARGET) were linked to increased heart failure risk (1.32 times higher than ICB).
Chemotherapy (CHEMO) increased coronary artery disease risk (1.28 times higher than ICB), and platinum-taxane combinations showed 2.14 times higher coronary risk than antimetabolites.
Immune checkpoint blockade (ICB) was associated with higher pericardial disease risk (5.88 times higher than CHEMO).
ROS1/NTRK/MET inhibitors showed greater heart failure risk (OR=2.14) compared to EGFR inhibitors.
Anti-PD-L1 and anti-CTLA-4 therapies were associated with lower pericardial disease risk compared to anti-PD-1.

Conclusions:

ICB plus RT is a favorable option for NSCLC patients with high cardiovascular risk.
Caution is advised when using ROS1/NTRK/MET inhibitors and platinum-taxane chemotherapy due to increased heart failure and coronary risk.
Anti-PD-L1 and anti-CTLA-4 may be preferred over anti-PD-1 in patients susceptible to pericardial toxicity.