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Related Experiment Video

Updated: Mar 27, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Differential Gene Expression in Human Hippocampus With Aging.

Ander Saenz-Antoñanzas¹, Manuel Moreno-Valladares^1,2, Maider Muñoz-Culla^3,4,5

¹Group of Cellular Oncology, Biogipuzkoa (Biodonostia) Health Research Institute, San Sebastian, Spain.

|March 26, 2026

Summary

This summary is machine-generated.

Brain aging involves gene expression changes, particularly in the hippocampus. Researchers identified RAD23B as a key gene whose reduced expression correlates with aging and Alzheimer's disease.

Keywords:

RAD23B brain aging hippocampus transcriptome

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Published on: October 20, 2022

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Brain aging leads to functional decline, cognitive impairment, and neurodegenerative diseases.
Molecular mechanisms of human hippocampus aging are understudied.
Transcriptomic analysis offers insights into age-related brain changes.

Purpose of the Study:

To investigate age-related gene expression differences in the human hippocampus.
To identify specific genes associated with brain aging and cognitive decline.
To explore the role of RAD23B in brain aging and Alzheimer's disease.

Main Methods:

Transcriptomic analysis of hippocampal samples from individuals of different ages.
Differential gene expression analysis between young and old groups.
Correlation analysis to identify genes linked to chronological aging.
Analysis of RAD23B expression in human primary cell cultures and Alzheimer's disease patients.

Main Results:

Aged individuals showed differential gene expression related to inflammation, immune response, DNA repair, metabolism, and neural activity.
Six genes were significantly associated with chronological aging.
RAD23B mRNA and protein expression negatively correlated with age in the hippocampus.
RAD23B expression was lower in Alzheimer's disease patients and is crucial for neuronal and astrocyte survival.

Conclusions:

Dynamic gene expression changes occur during brain aging.
RAD23B is a significant gene linked to brain aging and Alzheimer's disease.
RAD23B may serve as a biomarker and regulator of cellular aging in the brain.