Delonix regia flower extract protects against diabetic cardiac remodeling via modulating eNOS/NO/cGMP and...

Area of Science:

• Cardiovascular Pharmacology
• Diabetic Cardiomyopathy Research
• Phytochemistry

Background:

• Diabetic cardiomyopathy is a significant complication of diabetes, leading to cardiac dysfunction and structural remodeling.
• Identifying novel therapeutic agents for diabetic cardiomyopathy is crucial for improving patient outcomes.

Purpose of the Study:

• To investigate the cardioprotective mechanisms of methanolic Delonix regia extract against diabetic cardiac remodeling.
• To elucidate the phytochemical constituents responsible for the observed therapeutic effects.

Main Methods:

• Phytochemical analysis of Delonix regia extract using liquid chromatography-tandem mass spectrometry.
• Induction of diabetes in a rodent model using a high-fructose/salt/fat diet and streptozotocin.
• Oral administration of the extract and assessment of cardiac function, structure, and molecular markers.

Main Results:

• Identification of fifty-nine phytoconstituents in the Delonix regia extract.
• The extract improved cardiac performance, normalized electrocardiographic indicators, and attenuated cardiac remodeling (reduced hypertrophy, structural distortions, and fibrosis).
• Modulation of apoptotic markers, increased endothelial nitric oxide synthase (eNOS), tetrahydrobiopterin, cyclic guanosine monophosphate (cGMP), and glutathione levels were observed.

Conclusions:

• Methanolic Delonix regia extract demonstrates therapeutic potential in mitigating left ventricular remodeling in diabetic cardiomyopathy.
• The cardioprotective effects are linked to the modulation of eNOS/NO/cGMP and NF-κB/iNOS/TNF-α pathways, alongside anti-apoptotic and anti-fibrotic actions.