Related Experiment Video
Updated: Jul 7, 2026
11:10
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
17.1K
Association between diabetes mellitus type 2 and cervical insufficiency: a retrospective case-control study
Chiara Tersigni1, Giuliana Beneduce2, Marianna Onori2
1Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Summary
Maternal abnormal glucose tolerance, specifically type 2 diabetes, is linked to cervical insufficiency (CI). Women with type 2 diabetes are eight times more likely to experience CI, increasing the risk of preterm birth.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Endocrinology
Background:
- Cervical insufficiency (CI) is a condition where the cervix cannot retain a pregnancy, leading to second-trimester loss or preterm birth.
- No established association exists between CI and maternal abnormal glucose tolerance (AGT).
Purpose of the Study:
- To investigate a potential association between cervical insufficiency (CI) and maternal abnormal glucose tolerance (AGT).
Main Methods:
- A retrospective case-control study involving women referred for CI and healthy controls.
- Fasting glucose levels and oral glucose tolerance tests (OGTT) were used to assess AGT.
- Multivariable logistic regression analyzed confounders like maternal age and BMI.
Main Results:
- Women with CI exhibited a significantly higher prevalence of type 2 diabetes mellitus (DM2) (11/96 vs. 1/96, p < 0.01).
- Higher rates of vaginal/cervical infections and chorioamnionitis were observed in women with CI.
- Pregnant women with DM2 were eightfold more likely to have CI.
Conclusions:
- A significant association exists between type 2 diabetes mellitus and cervical insufficiency.
- Maternal abnormal glucose tolerance may be a risk factor for cervical insufficiency and subsequent pregnancy complications.
Keywords:
Cervical insufficiencyabnormal glucose tolerancediabetes mellitus type 2preterm birthsecond-trimester fetal lossMore Related Videos
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
10.3K
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
1.1K
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...