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Exercise training preferentially modulates α1D-adrenergic receptor expression in peripheral arteries of hypertensive
Ling-Zhi Li1, Meng Li1, Tong Deng2
1Pain Department, Affiliated Hospital of Hebei University, Baoding, 071000, China.
Abstract:
To evaluate the relative expression of α1D, P2X1, and P2Y6 receptor mRNAs in arterial tissues (renal artery [RA], thoracic aorta [Aor], and caudal artery [Cau]) of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and to assess exercise-induced changes, SHR and WKY rats were assigned to sedentary (S) or exercise training (E) groups. The E group underwent 16 weeks of treadmill training. Systolic blood pressure (SBP) decreased significantly in SHR-E rats. Receptor mRNA expression followed P2X1 > α1D > P2Y6, with P2X1 highest in the Cau and α1D highest in the Aor. SHR rats showed lower expression in all arteries compared to WKY. Exercise training had a greater effect on α1D receptors, while P2X1 remained predominant. In SHR-E rats, expression decreased for all receptors except α1D in the Cau, which increased. The distribution of α1D and P2X1 receptors correlates with vascular diameter and hypertension. Exercise impacts α1D receptors more, particularly in peripheral arteries. P2X1 dominance in peripheral arteries persists post-exercise, possibly aiding blood redistribution during exercise and maintaining organ function.
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