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Updated: Mar 27, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Very low-density lipoprotein and the human health
Alok Bharadwaj1, Manas Taneja2, Sneha Dubey2
1Department of Biotechnology, GLA University, Mathura 281406, Uttar Pradesh, India. alok.bhardwaj@gla.ac.in.
World Journal of Experimental Medicine
|March 26, 2026
Summary
Very low-density lipoprotein (VLDL) plays a key role in transporting lipids but also significantly contributes to cardiovascular disease and other illnesses. Understanding VLDL
Area of Science:
- Lipid Metabolism and Cardiovascular Health
- Endocrinology and Metabolic Diseases
Background:
- Very low-density lipoprotein (VLDL) is crucial for lipid transport, containing apolipoprotein B, a cardiovascular risk marker.
- VLDL contributes significantly to the development of atherosclerotic heart disease and metabolic syndrome complications.
Purpose of the Study:
- To comprehensively review the physiological functions of VLDL.
- To summarize evidence supporting VLDL's pathological roles in various diseases.
Main Methods:
- Literature review of VLDL's physiological and pathological roles.
- Analysis of data linking VLDL to atherosclerosis, metabolic syndrome, and other conditions.
Main Results:
- VLDL promotes atherosclerosis and is cytotoxic to atrial myocytes, contributing to atrial fibrillation.
- VLDL is implicated in hypertension, neuroinflammation, chronic kidney disease, autoimmune disorders, skin diseases, cancer, and sleep disturbances.
- Endocrine diseases and intestinal dysbiosis can impact VLDL levels and metabolism.
Conclusions:
- VLDL is implicated in a wide range of pathologies beyond cardiovascular disease.
- Further research into VLDL metabolism is crucial for understanding and treating numerous illnesses.
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