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Published on: December 15, 2011
A Challenging Case of Trimethoprim-Sulfamethoxazole Associated Drug Reaction With Eosinophilia and Systemic Symptoms
Anusha Baddam1, Peter P Chow2,3, Daffolyn Rachael Fels Elliott2
1Mallareddy Medical College for Women, Hyderabad, Telangana, India.
Abstract:
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening hypersensitivity reaction that manifests with a spectrum of cutaneous and systemic involvement. We present an unusual case of DRESS in a 26-year-old man with markedly elevated liver enzymes and hyperbilirubinemia but relatively limited skin activity. The patient had a recent diagnosis of human immunodeficiency virus infection and was treated with trimethoprim-sulfamethoxazole for Pneumocystis jirovecii pneumonia and bilateral pneumothoraces. This case emphasizes the importance of maintaining a high clinical suspicion for DRESS in patients presenting with elevated liver enzymes and skin rash.
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