Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

848
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
848
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model01:14

Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model

81
The link model is a fundamental pharmacokinetic-pharmacodynamic (PK–PD) approach to account for delayed drug responses when the observed effect does not immediately correlate with the drug's plasma concentration peak. This delay is mathematically addressed by introducing an effect compartment concentration, Ce, which is kinetically linked to the plasma concentration, Cp, via a first-order rate constant, ke0. The linkage allows for a more accurate prediction of drug effects over time. A...
81
Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

698
Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
698
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.7K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.7K
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

903
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
903
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

7.6K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision acupuncture: Moving from art to evidence-based science.

Acupuncture in medicine : journal of the British Medical Acupuncture Society·2026
Same author

Mapping Acupoint Networks for Chronic Pelvic Pain: A Review-Based Network Analysis of Randomized Trials.

Pain research & management·2026
Same author

From fixed points to probabilistic maps: A spatial framework for acupoint localization.

Integrative medicine research·2026
Same author

Decoding acupoint specificity: from neural patterns to bodily maps.

Frontiers in neuroscience·2026
Same author

Altered brain connectivity in sensory and motor cortices underlying atopic dermatitis.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches.

Molecular pain·2026

Related Experiment Video

Updated: Mar 27, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

5.8K

A new framework for acupoint specificity: Advancing acupuncture studies using the double-dissociation model.

Younbyoung Chae1, Da-Eun Yoon1, Cheng-Hao Tu2

  • 1Department of Meridian and Acupoints, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Integrative Medicine Research
|March 26, 2026
PubMed
Summary

This study proposes a novel double-dissociation framework to rigorously test acupoint specificity. This research aims to provide stronger evidence for functional specialization in acupuncture points, advancing scientific understanding.

Keywords:
Acupoint specificityAcupunctureDouble dissociationExperimental design

More Related Videos

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice
04:55

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

Published on: May 11, 2022

5.0K
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.2K

Related Experiment Videos

Last Updated: Mar 27, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

5.8K
A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice
04:55

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

Published on: May 11, 2022

5.0K
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.2K

Area of Science:

  • Integrative Medicine
  • Neuroscience
  • Physiology

Background:

  • Acupoint specificity is debated in modern science due to inconsistent methodologies.
  • Previous research often relies on single-dissociation, limiting causal inferences.
  • A need exists for rigorous frameworks to validate acupoint-specific effects.

Purpose of the Study:

  • To introduce a double-dissociation research framework for testing functional acupoint specificity.
  • To provide a robust methodology for stronger causal inferences in acupuncture research.
  • To stimulate empirical studies on acupoint-specific effects.

Main Methods:

  • Proposing a double-dissociation paradigm comparing two acupoints (PC6 and ST36).
  • Assessing selective modulation of distinct physiological domains (cardiovascular vs. gastric).
  • Defining double dissociation as crossed selectivity in physiological effects.

Main Results:

  • A double dissociation would demonstrate PC6's selective cardiovascular influence and ST36's selective gastric influence.
  • Evidence of crossed selectivity supports functional acupoint specificity.
  • The proposed framework offers a proof-of-concept for future empirical validation.

Conclusions:

  • The double-dissociation framework provides a rigorous approach to investigate acupoint specificity.
  • Demonstrating crossed selectivity strengthens evidence for functional specialization of acupuncture points.
  • This methodology aligns acupuncture research with contemporary scientific standards.