Evolving PCOS Management: From Symptom Control to Phenotype-Targeted Therapy

Area of Science:

• Endocrinology and metabolic disorders
• Reproductive health
• Multisystemic conditions

Background:

• Polycystic ovary syndrome (PCOS) is a widespread endocrine and metabolic disorder impacting reproductive and metabolic health in women of reproductive age.
• The increasing global prevalence of PCOS necessitates innovative, interdisciplinary management strategies.
• Current reviews lack a comprehensive synthesis of recent advancements in PCOS clinical management.

Purpose of the Study:

• To provide a distinctive synthesis of recent advances in PCOS clinical management.
• To focus on integrating lifestyle modifications, pharmacological interventions, assisted reproductive techniques, and emerging therapies.
• To critically evaluate the efficacy, mechanisms, and limitations of current and emerging PCOS management strategies.

Main Methods:

• Comprehensive literature review of recent advances in PCOS management.
• Synthesis of clinical data on lifestyle modifications, pharmacological interventions, and assisted reproductive techniques.
• Evaluation of emerging therapeutic approaches, including digital health tools and personalized medicine.

Main Results:

• Identified key advancements in integrating diverse therapeutic modalities for PCOS.
• Highlighted the efficacy and limitations of various pharmacological and lifestyle interventions.
• Recognized the potential of digital health and personalized medicine in future PCOS care.

Conclusions:

• An integrated, interdisciplinary approach is crucial for effective PCOS management.
• Further research is needed to address underexplored gaps in PCOS knowledge and practice.
• Personalized medicine and digital health tools offer promising avenues for improving clinical outcomes and patient-centered care in PCOS.