Beer Intake is Positively, While Cheese and Dried Fruit Intake Are Negatively Genetically Correlated with Psoriasis:...

Area of Science:

• Genetics
• Nutritional Epidemiology
• Genomics

Background:

• Previous studies suggest links between beer, cheese, and dried fruit intake and psoriasis (PS).
• The shared genetic basis for these associations is not well understood.
• Genomic investigation is crucial to explore molecular relationships.

Purpose of the Study:

• To examine the genome-wide and local genetic overlap between psoriasis and intake of beer, cheese, and dried fruit.
• To identify shared genetic loci contributing to these associations.
• To enhance understanding of nutrition-disease molecular mechanisms.

Main Methods:

• Utilized genome-wide association study data for psoriasis and dietary intake.
• Employed linkage disequilibrium score regression, genetic covariance, and high-definition likelihood for genome-wide genetic correlations.
• Applied conditional/conjunctional false discovery rate (condFDR/conjFDR) for shared locus identification.

Main Results:

• Consistent genome-wide genetic correlations were found between psoriasis and the three dietary traits.
• Psoriasis showed positive genetic correlation with beer intake and negative correlations with cheese and dried fruit intake.
• Multiple chromosomal regions and significant shared genetic loci were identified between psoriasis and dietary patterns.

Conclusions:

• This study systematically characterized the genetic overlap between psoriasis and dietary intake.
• Identified shared genetic loci provide insights into nutrition-disease molecular mechanisms.
• Findings offer genetic evidence for future research and risk-modification strategies.