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Fibulin-7 Promotes Short-term Histological Bone-Tendon Interface Healing in a Murine Rotator Cuff Repair Model.

Junhao Li1,2,3, Huabin Chen4,5, Weikun Zheng1,2,3

  • 1The First Clinical Medical College of Jinan University, Guangzhou, China.

Orthopaedic Journal of Sports Medicine
|March 26, 2026
PubMed
Summary

Fibulin-7 (FBLN7) significantly improves rotator cuff repair in aged mice by enhancing bone-tendon healing. This protein shows promise for improving recovery in older patients undergoing surgery.

Keywords:
FBLN7agingbone-tendon interfacerotator cuff repair

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Gerontology

Background:

  • Aging impairs bone-tendon healing at the bone-tendon interface (BTI) during rotator cuff repair.
  • Fibulin-7 (FBLN7) has potential regenerative properties relevant to BTI healing in aged populations.

Purpose of the Study:

  • To investigate if FBLN7 enhances tendon-bone healing and regeneration in aging mice following rotator cuff repair.

Main Methods:

  • Aged mice underwent rotator cuff repair with either FBLN7-enhanced fibrin sealant or standard sealant.
  • Evaluations included micro-CT, histology, and biomechanical testing at 4 and 8 weeks post-surgery.

Main Results:

  • Aged mice showed lower FBLN7 expression at the BTI compared to young mice.
  • The FBLN7 group demonstrated improved bone morphology, increased bone density, and enhanced biomechanical properties (failure load, stiffness).
  • FBLN7 treatment led to superior fibrocartilage formation and upregulated key osteogenic, chondrogenic, and tenogenic factors.

Conclusions:

  • FBLN7 significantly promotes healing and regeneration at the bone-tendon interface in aged mice.
  • FBLN7 represents a potential therapeutic strategy to improve rotator cuff repair outcomes in elderly patients.