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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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The guardian of the genome meets immunotherapy: p53-based strategies

Tatyana A Savostyanova1,2, Julia A Lopatnikova1, Sergey V Sennikov1,3

  • 1Laboratory of Molecular Immunology, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.

Frontiers in Immunology
|March 26, 2026
PubMed

Insights

The p53 protein, a key genome guardian, plays a crucial role in preventing human cancers. This review explores p53

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The p53 protein, initially identified as an oncogene, is now recognized as a critical "genome guardian."
  • p53 protein dysfunction is implicated in the majority of human cancers, highlighting its importance in cancer development.
  • Understanding p53's regulatory mechanisms and therapeutic potential is a major focus in cancer research.

Purpose of the Study:

  • To review the regulation and functionality of the p53 protein.
  • To analyze the role of p53 in tumor evolution.
  • To provide a comprehensive overview of current and emerging therapeutic strategies targeting p53, including immunotherapy.

Main Methods:

  • Literature review of p53 regulation and function.
  • Analysis of p53's role in cancer development and progression.
  • Synthesis of information on therapeutic strategies targeting p53.

Main Results:

  • p53 exhibits diverse functions beyond transcription regulation.
  • p53 plays a significant role in tumor evolution.
  • Various therapeutic strategies, especially immunotherapy, are being developed to target p53.

Conclusions:

  • p53 is a vital tumor suppressor with complex regulatory networks.
  • Targeting p53 offers promising therapeutic avenues for cancer treatment.
  • Immunotherapy approaches targeting p53 represent a significant area of ongoing research and development.
Keywords:
TP53 mutationsadoptive TCR-T therapygene replacement therapyp53 neoantigensp53-based vaccinestumor suppressor protein p53

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