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Updated: Mar 27, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
Published on: December 17, 2019
Macrophage Efferocytosis in Heart
Hiroyasu Inui1, Xiangyu Yu2, Eric Pfrender1
1Northwestern University, Feinberg School of Medicine, Department of Pathology (H.I., E.P., J.B., E.B.T.).
Abstract:
Efficient clearance of dying cells by efferocytosis is critical for organ development, inflammation resolution, and tissue repair. In the heart, the stakes of efficient clearance are high in that inefficient efferocytosis promotes an inflammatory environment that stresses the health of surrounding nonregenerative cardiomyocytes. Herein, we discuss the fundamental protagonists and therapeutic implications of efferocytosis within the myocardium during cardiac development, myocardial regeneration, and myocardial infarction.
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